منابع مشابه
The mouse prolactin gene family locus.
In the mouse, there is a large family of paralogous genes closely related to PRL. The objective of this report was to investigate the organization of the mouse PRL gene family locus. PRL family genes reside on chromosome 13 of the mouse genome. The PRL gene family members were localized to a series of overlapping bacterial artificial chromosome clones and arranged based on structural relationsh...
متن کاملCharacterization of the mouse collectin gene locus.
Three of the four known mouse collectin genes have been mapped to chromosome 14. To further characterize the spatial relationship of these genes, a bacterial artificial chromosome (BAC) library of mouse chromosome 14 was screened using mouse surfactant protein (SP)-A and -D complementary DNAs (cDNAs). One large clone hybridized to both SP-A and SP-D cDNAs and was found by polymerase chain react...
متن کاملThree novel paralogs of the rodent prolactin gene family.
The prolactin (PRL) family consists of a collection of genes expressed in the uterus, placenta and anterior pituitary. These cytokines/hormones participate in the control of maternal-fetal adaptations to pregnancy. In this report, we establish the presence of three new members of the PRL family. Novel expressed sequence tags (ESTs) with homology to PRL were isolated from embryonic and placental...
متن کاملDefining the function of a prolactin gene family member.
T he quotation above is a considerable understatement for all of those graduate students and postdoctoral researchers whose hopes for scientific glory, or at least a diploma, were resting on a phenotype resulting from the ablation of their gene of interest. The source of this consternation is functional redundancy, and paralogous gene families are at least one source of such redundancy. The per...
متن کاملHormone/Prolactin Receptor Family
Recent findings from this laboratory suggest that the biological actions of placental lactogen (PL) in mammalian fetal tissues are mediated through binding of the hormone to a distinct and unique PL receptor. We have now purified this receptor from fetal and maternal sheep liver, characterized its binding to PL, growth hormone (GH), and prolactin (PRL), and determined its molecular weight by SD...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2003
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2002-220724